I am having the same exact problem. I have a brand new desktop pc running Vista Home Premium x64. Every since the initial boot I have had problems with the screen saver resetting to 1 after every reboot. I have searched high and low and there are many suggestions out there to fix it, but none of them worked for me. I do have a older Microsoft Wireless Optical Mouse 2.0 installed. Many of the blogs out there reference this as the problem, including Microsoft itself, but the fixes have not worked for me. I removed the wireless mouse and all associated software and drivers and installed a straight USB wired mouse and let Windows install the recommended driver for it. Still the same problem. I have no other wireless devices installed, no external drives, nothing but a plain Jane system. Any help would be greatly appreciated. Thanks...