Hello fred54321,
If you had ten answers to your post every one would recommend a different optimizer, what is it that you want tune up ?, i have found that you can do everything that these optimizers do just by optimizing Vista to take full advantage of your hardware.
In the end, you cant make a system or a component run faster or better than it's designed to. If you need any help in tuning up your system, i will be happy to help as will everybody on this forum.
Good luck and if you need or want help just shout.