I run windows Vista 32bit. For a while my mouse has taken between 1-120 seconds to start up when leaving sleep mode. Since updating my system with the normal windows update it asked me to do the mouse no longer wakes up. Even unplugging it from the usb and trying it in all the other ports will not get it to work. The keyboard works fine and i have to use it to restart the computer to get the mouse to work. Ive tried a couple of different mice and it happens on both of them. My current mouse is a logitech G500 and the problem has only been since the update a few days ago.