Autoplay in non-removable hard disk

My Vista Ultimate 32bit, with autoplay is a non-removable drive ( D: ). How to solve?

You can start by explaining in detail what you mean - do you have a non removable drive that is trying to start up every time you boot with autoplay, or is Vista trying to load a non existent drive, or what?

Remember, we cannot see, touch, or interact with the machine - so you have to be our eyes and ears (and hands) for us - and in order to direct you correctly we have to know *exactly* what is going on.

My drive D: is with the option of autoplay, and the D: is a fixed disk drive

does it automatically pop up? What is on the D drive? is this a laptop or a desktop?

It is a notebook, only that the disc D: is with the autoplay, I would like to remove this

You might want to elaborate a little more on what is trying to autoplay. Also is this autoplaying when the computer boots up or randomly? Like he said before, we can not physically see your screen or interact with it so more details really helps us help you. You can also disable auto play in Windows so this does not happen.

This article might help in disabling the autoplay feature
Disable AutoPlay in Windows Vista :: the How-To Geek

If more help is needed please provide more info.